Thiamine Hydrochloride

Class: Vitamin B Complex
VA Class: VT105
Chemical Name: thiazolium,3- [(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-chloride, monochloride
CAS Number: 67-03-8

Introduction

Water-soluble, B complex vitamin.^a

Uses for Thiamine Hydrochloride

Thiamine Deficiency

Treatment of thiamine deficiency syndromes (e.g., beriberi, Wernicke’s encephalopathy syndrome). ^b

Dietary Requirements

Adequate intake needed to prevent thiamine deficiency (beriberi).¹⁰⁹

Adequate thiamine intake can be accomplished through consumption of foodstuffs.¹⁰⁹ Enriched, fortified, or whole grain products; bread and bread products; mixed foods with grain as a main ingredient; and ready-to-eat cereals are the major contributors of thiamine in the diet of US adults and children.¹⁰⁹

Recommended Dietary Allowance (RDA) in adults based on erythrocyte transketolase activity, urinary thiamine excretion, and other findings.¹⁰⁹

Requirements slightly lower in women than men based on women's size and average energy utilization.¹⁰⁹

Adequate intake (AI) established for infants ≤6 months of age based on observed mean thiamine intake of infants fed principally human milk; AI for infants 7–12 months of age based on AI for younger infants and data in adults.¹⁰⁹

RDA for children 1–18 years of age based on data in adults.¹⁰⁹

Metabolic Disorder

Has been used in thiamine-responsive maple syrup urine disease† and subacute necrotizing encephalomyelopathy† (Leigh's disease).^a

Thiamine Hydrochloride Dosage and Administration

Administration

Usually administered orally.^a May be administered by IV or IM injection when indicated or when oral administration is not feasible.^b

For solution and drug compatibility information, see Compatibility under Stability.

Dosage

Available as thiamine hydrochloride; dosage expressed in terms of the salt.^{a b}

Pediatric Patients

Thiamine Deficiency

Oral

Noncritically ill children: 10–50 mg daily, given in divided doses.^a

IM or IV

Critically ill children (e.g., infantile beriberi): 10–25 mg.^{a b}

Dietary and Replacement Requirements

Oral

Infants ≤6 months of age: Recommended AI is 0.2 mg (0.03 mg/kg) daily.¹⁰⁹

Infants 7–12 months of age: Recommended AI is 0.3 mg (0.03 mg/kg) daily.¹⁰⁹

Children 1–3 years of age: RDA is 0.5 mg daily.¹⁰⁹

Children 4–8 years of age: RDA is 0.6 mg daily.¹⁰⁹

Children 9–13 years of age: RDA is 0.9 mg daily.¹⁰⁹

Boys 14–18 years of age: RDA is 1.2 mg daily.¹⁰⁹

Girls 14–18 years of age: RDA is 1 mg daily.¹⁰⁹

RDAs not expected to meet the needs of those with malabsorption syndrome or undergoing hemodialysis or peritoneal dialysis.¹⁰⁹

Adults

Thiamine Deficiency

Oral

Noncritically ill adults: 5–30 mg daily, as a single dose or 3 divided doses, for 1 month.^a

IV followed by IM

Wernicke's syndrome: Initially 100 mg IV, followed by 50–100 mg IM daily until patient can consume a balanced diet.^b

IV or IM

Critically ill thiamine-deficient adult or patient with malabsorption syndrome: 5–100 mg 3 times daily.^a

IM

Beriberi: 10–20 mg 3 times daily for up to 2 weeks.^b

Dietary and Replacement Requirements

Oral

Men ≥19 years of age: RDA is 1.2 mg daily.¹⁰⁹

Women ≥19 years of age: RDA is 1.1 mg daily.¹⁰⁹

RDAs not expected to meet the needs of those with malabsorption syndrome or undergoing hemodialysis or peritoneal dialysis.¹⁰⁹

Prescribing Limits

Single doses >30 mg not likely to be utilized.^a

Special Populations

Pregnant Women

RDA for pregnant women is 1.4 mg daily.¹⁰⁹

Thiamine intake >1.4 mg daily needed by women who are pregnant with >1 fetus.¹⁰⁹

Requirements increased in pregnant women to cover increased energy utilization and growth in the maternal and fetal compartments.¹⁰⁹

Lactating Women

RDA for lactating women is 1.5 mg daily.¹⁰⁹

Thiamine intake >1.5 mg daily needed by women who are nursing >1 infant.¹⁰⁹

Requirements increased in lactating women to ensure adequate concentration of the vitamin in milk.¹⁰⁹

Cautions for Thiamine Hydrochloride

Contraindications

Known sensitivity to thiamine or any ingredient in formulation.^{a b}

Warnings/Precautions

Sensitivity Reactions

Hypersensitivity Reactions

Possible severe hypersensitivity reactions/anaphylaxis, especially following repeated parenteral administration.^b

Skin Test

Administer an intradermal test dose prior to parenteral administration of therapeutic doses of thiamine in patients who may be sensitive to the drug.^b

General Precautions

Aluminum Content

Some thiamine hydrochloride injection preparations contain aluminum, which may be toxic.^b Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired.^b Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.^b

Research indicates that patients with impaired kidney function, including premature neonates, who receive aluminum parenterally in quantities of >4–5 mcg/kg daily accumulate aluminum at levels associated with CNS and bone toxicity.^b Tissue loading may occur at even lower rates of administration.^b

Specific Populations

Pregnancy

Category A.^b

Lactation

Distributed into milk.^a Caution if parenteral preparation is used in nursing women.^b

Common Adverse Effects

Relatively nontoxic; feelings of warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness, angioedema, tightness in the throat, cyanosis, pulmonary edema, GI bleeding reported with parenteral administration.^{a b}

Interactions for Thiamine Hydrochloride

Specific Drugs and Laboratory Tests

Drug	Interaction	Comments
Neuromuscular blocking agents	Possible enhanced neuromuscular blocking actiona	Clinical importance unknowna
Schack and Waxler determination of serum theophylline concentrations	Large doses of thiamine may interfere with this testa
Test for uric acid	Possible false-positive result with the phosphotungstate methoda
Test for urobilinogen using Ehrlich's reagent	Possible false-positive resulta

Thiamine Hydrochloride Pharmacokinetics

Absorption

Bioavailability

Small doses are readily absorbed from the GI tract.^a

Completely absorbed following IM administration.^b

Food

Rate, but not extent, of GI absorption is decreased when administered with meals.^a

Distribution

Extent

Distributed into all tissues; highest concentrations in liver, brain, kidney, and heart.^b

Elimination

Elimination Route

Excreted in urine as unchanged drug and metabolites.^a

Stability

Storage

Oral

Tablets

Tight, light-resistant container at <40°C; preferably between 15–30°C.^a

Parenteral

Injection

20–25°C.^b Protect from light.^b

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Parenteral

Solution Compatibility^HID

Compatible
Dextran 6% in dextrose 5%
Dextran 6% in sodium chloride 0.9%
Dextrose–Ringer's injection combinations
Dextrose-Ringer’s injection, lactated, combinations
Dextrose-saline combinations
Dextrose 2½, 5, or 10% in water
Fat emulsion 10%, IV
Fructose 10% in sodium chloride 0.9%
Fructose 10% in water
Invert sugar 5 and 10% in sodium chloride 0.9%
Invert sugar 5 and 10% in water
Ionosol products
Ringer's injection
Ringer's injection, lactated
Sodium chloride 0.45 or 0.9%
Sodium lactate (1/6) M

Drug Compatibility

Y-Site CompatibilityHID

Compatible
Famotidine

ActionsActions

• 
  

  An exogenous source of thiamine is required for carbohydrate metabolism. ^a

  
  


• 
  

  Functions as a coenzyme in the metabolism of carbohydrates and branched-chain amino acids.¹⁰⁹

  
  

Advice to Patients

• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.^a

  
  


• 
  

  Importance of proper dietary habits, including taking appropriate AI or RDA of thiamine.¹⁰⁹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^a

  
  


• 
  

  Importance of informing patients of other important precautionary information.^a (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Thiamine Hydrochloride

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Bulk	Powder*
Oral	Tablets	25 mg*
		50 mg*
		100 mg*
		250 mg*
		500 mg*
Parenteral	Injection	100 mg/mL*

Thiamine salts are also commercially available for oral use in combination with other vitamins, minerals, amino acids, protein supplements, and infant formulas. For IV infusion, thiamine hydrochloride is commercially available in combination with other vitamins in caloric and electrolyte solutions.^a

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions September 01, 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

References

100. Food and Drug Administration. Insect repellent drug products for over-the-counter oral human use. [21 CFR Part 310] Fed Regist. 1985; 50:25170-1.

101. Food and Drug Administration. Insect repellent drug products for over-the-counter oral human use. [21 CFR Part 310] Fed Regist. 1982; 47:424-7.

102. Food and Drug Administration and American Society for Parenteral and Enteral Nutrition. Deaths associated with thiamine-deficient total parenteral nutrition. MMWR Morb Mortal Wkly Rep. 1989; 38:43-6. [IDIS 250221] [PubMed 2492074]

103. Velez RJ, Myers B, Guber MS. Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. J Parenter Enteral Nutr. 1985; 9:216-9.

104. Mattioli S, Miglioli M, Montagna P et al. Wernicke’s encephalopathy during total parenteral nutrition: observation in one case. J Parenter Enteral Nutr. 1988; 12:626-7.

105. Reuler JB, Girard DE, Cooney TG. Wernicke’s encephalopathy. N Engl J Med. 1985; 312:1035-8. [IDIS 198729] [PubMed 3885034]

106. National Research Council Food and Nutrition Board Subcommittee on the Tenth Edition of the RDAs. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press; 1989:125-32.

107. Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multivitamins for total parenteral nutrition–United States, 1997. MMWR. 1997; 46:523-8. (Also published in JAMA. 1997; 278:109-11.)

108. American Society for Parenteral and Enteral Nutrition (ASPEN). Multivitamin shortage–Update #17: fatality reported. Press release. 1997 Jul 21.

109. Committee on the Scientific Evaluation of Dietary Reference Intakes of the Food and Nutrition Board, Institute of Medicine, National Academy of Sciences. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B₆, folate, vitamin B₁₂, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press; 1998. (Prepublication copy uncorrected proofs.)

110. American Psychiatric Association. Practice guidelines for the treatment of patients with delirium. Am J Psychiatry. 1999; 156(Suppl 5):1-20.

a. AHFS drug information 2007. McEvoy GK, ed. Thiamine. Bethesda, MD: American Society of Health-Systems Pharmacists; 2007: 3626-7.

b. Abraxis Pharmaceuticals. Thiamine injection prescribing information. Schaumburg, IL; 2005 Jun.

HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1538-40.

More Thiamine Hydrochloride resources

• Thiamine Hydrochloride Side Effects (in more detail)
• Thiamine Hydrochloride Use in Pregnancy & Breastfeeding
• Thiamine Hydrochloride Support Group
• 0 Reviews for Thiamine Hydrochloride - Add your own review/rating

• thiamine Concise Consumer Information (Cerner Multum)


• thiamine Oral, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Thiamine MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Thiamine Hydrochloride with other medications

• Beriberi
• Vitamin B1 Deficiency
• Vitamin/Mineral Supplementation and Deficiency
• Wernicke's Encephalopathy

propafenone

proe-PA-fen-one hye-droe-KLOR-ide

Oral route(Tablet;Capsule, Extended Release)

It is prudent to consider any Class 1C antiarrhythmic to have a significant proarrhythmic risk in patients with structural heart disease. Given the lack of any evidence that these drugs improve survival, antiarrhythmic agents should generally be avoided in patients with non-life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs .

Commonly used brand name(s)

In the U.S.

• Rythmol


• Rythmol SR

Available Dosage Forms:

• Capsule, Extended Release


• Tablet

Therapeutic Class: Antiarrhythmic, Group IC

Chemical Class: Propafenone

Uses For propafenone

Propafenone is used to prevent irregular heartbeats such as atrial fibrillation (AF) from occurring again in patients who do not have structural heart disease.

Propafenone belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal.

There is a chance that propafenone may cause new or make worse existing heart rhythm problems when it is used. Since it has been shown to cause severe problems in some patients, propafenone is only used to treat serious heart rhythm problems. Discuss this possible effect with your doctor.

propafenone is available only with your doctor's prescription.

Before Using propafenone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For propafenone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to propafenone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propafenone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propafenone in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking propafenone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using propafenone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil


• Cisapride


• Dronedarone


• Levomethadyl


• Mesoridazine


• Pimozide


• Posaconazole


• Ritonavir


• Saquinavir


• Sparfloxacin


• Terfenadine


• Thioridazine


• Tipranavir


• Ziprasidone

Using propafenone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide


• Ajmaline


• Alfuzosin


• Amiodarone


• Amisulpride


• Amitriptyline


• Amoxapine


• Apomorphine


• Aprindine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Azimilide


• Azithromycin


• Boceprevir


• Bretylium


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Crizotinib


• Darunavir


• Dasatinib


• Delavirdine


• Desipramine


• Dibenzepin


• Digoxin


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Duloxetine


• Eltrombopag


• Enflurane


• Erythromycin


• Etravirine


• Flecainide


• Fluconazole


• Fluoxetine


• Foscarnet


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Halothane


• Hydroquinidine


• Ibutilide


• Iloperidone


• Imipramine


• Isoflurane


• Isradipine


• Lapatinib


• Levofloxacin


• Lidocaine


• Lidoflazine


• Lopinavir


• Lorcainide


• Lumefantrine


• Mefloquine


• Methadone


• Moxifloxacin


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ondansetron


• Paliperidone


• Pazopanib


• Pentamidine


• Perflutren Lipid Microsphere


• Pirmenol


• Prajmaline


• Prilocaine


• Probucol


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Risperidone


• Salmeterol


• Sematilide


• Sertindole


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Spiramycin


• Sulfamethoxazole


• Sultopride


• Sunitinib


• Tedisamil


• Telaprevir


• Telithromycin


• Tetrabenazine


• Tizanidine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Vandetanib


• Vardenafil


• Vasopressin


• Vemurafenib


• Voriconazole


• Zolmitriptan


• Zotepine

Using propafenone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bupropion


• Clozapine


• Cyclosporine


• Metoprolol


• Paroxetine


• Rifampin


• Rifapentine


• Sertraline


• Theophylline


• Tolterodine


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of propafenone. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma or


• Bronchitis or


• Emphysema—Propafenone can increase trouble in breathing.

• AV block (type of abnormal heart rhythm), with no pacemaker or


• Bradycardia (slow heartbeat) or


• Breathing problems or lung disease (e.g., bronchospasm, severe obstructive pulmonary disease) or


• Cardiogenic shock (shock caused by heart attack) or


• Heart failure or


• Hypotension (low blood pressure) or


• Mineral imbalance or


• Sick sinus node syndrome (type of abnormal heart rhythm) with no pacemaker—Should not be used in patients with these conditions.

• Blood or bone marrow problems (e.g., agranulocytosis, granulocytopenia) or


• Coronary artery disease or


• Heart rhythm problems (e.g., QT prolongation) or


• Myasthenia gravis (severe muscle weakness) or


• Torsade de pointes or


• Ventricular fibrillation or tachycardia—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• If you have a permanent pacemaker—Use with caution. Propafenone may interfere with the pacemaker and require more careful follow-up by the doctor.

Proper Use of propafenone

Take propafenone exactly as directed by your doctor. Do not take more or less of propafenone, and do not take it more often than your doctor ordered.

For patients taking the extended-release capsules:

• Swallow the capsules whole. Do not crush, break, or chew them.


• propafenone may be taken with or without food.

propafenone works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. For example, if you are to take 3 doses a day, doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your doctor.

Your doctor may want you to carry a medical identification card or bracelet stating that you are using propafenone.

Dosing

The dose of propafenone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of propafenone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• The number of extended-release capsules or tablets that you take depends on the strength of the medicine.


• For atrial fibrillation (AF):
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 225 milligrams (mg) every 12 hours. Your doctor may increase your dose as needed. However, the dose is usually not more than 425 mg every 12 hours.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For oral dosage forms (tablets):
    
    • Adults—150 milligrams (mg) every 8 hours. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of propafenone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using propafenone

It is important that your doctor check your progress at regular visits to make sure the medicine is working properly. This will allow for changes to be made in the amount of medicine you are taking, if necessary.

propafenone can cause changes in your heart rhythm, such as conditions called PR, QRS, or QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if your symptoms do not improve or if they get worse.

Check with your doctor right away if you develop any of the following: chest pain; shortness of breath; swelling of your hands, ankles, or feet; or weight gain. These may be symptoms of heart failure.

propafenone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Make sure any doctor or dentist who treats you knows that you are using propafenone. propafenone may affect the results of certain medical tests.

Propafenone may cause some people to become dizzy or lightheaded. Make sure you know how you react to propafenone before you drive, use machines, or do anything else that could be dangerous if you are dizzy.

If you have been using propafenone regularly for several weeks, do not suddenly stop using it. Check with your doctor for the best way to gradually reduce the amount you are taking before stopping completely.

propafenone may decrease the amount of sperm men make. Talk to your doctor if you have concerns about this.

Grapefruits and grapefruit juice may increase the effects of propafenone by increasing the amount of propafenone in your body. You should not eat grapefruit or drink grapefruit juice while you taking propafenone.

Tell your doctor if you are smoking tobacco.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

propafenone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Chest pain


• fast, irregular, or slow heartbeat


• lightheadedness, dizziness, or fainting


• shortness of breath


• swelling of the feet or lower legs


• weight gain

Rare

• Chills


• fever


• joint pain


• trembling or shaking


• weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Change in taste or bitter or metallic taste

Less common

• Blurred vision


• constipation


• diarrhea


• dryness of the mouth


• headache


• nausea or vomiting


• skin rash


• unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: propafenone side effects (in more detail)

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More propafenone resources

• Propafenone Side Effects (in more detail)
• Propafenone Use in Pregnancy & Breastfeeding
• Drug Images
• Propafenone Drug Interactions
• Propafenone Support Group
• 20 Reviews for Propafenone - Add your own review/rating

• propafenone Concise Consumer Information (Cerner Multum)


• Propafenone Prescribing Information (FDA)


• Propafenone MedFacts Consumer Leaflet (Wolters Kluwer)


• Propafenone Professional Patient Advice (Wolters Kluwer)


• Propafenone Hydrochloride Monograph (AHFS DI)


• Rythmol Prescribing Information (FDA)


• Rythmol SR Prescribing Information (FDA)


• Rythmol SR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare propafenone with other medications

• Atrial Fibrillation
• Atrial Flutter
• Ventricular Tachycardia
• Wolff-Parkinson-White Syndrome

atovaquone and proguanil

Generic Name: atovaquone and proguanil (a TOE va kwone and pro GWAHN il)

Brand Names: Malarone, Malarone Pediatric

What is atovaquone and proguanil?

Atovaquone and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

The combination of atovaquone and proguanil is used to treat or prevent malaria.

Atovaquone and proguanil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about atovaquone and proguanil?

You should not use this medication if you are allergic to atovaquone or proguanil. You should not use this medication to prevent malaria if you have severe kidney disease.

Before using this medication, tell your doctor if you have liver or kidney disease, severe complications from infection with malaria, or uncontrolled vomiting or diarrhea.

Take atovaquone and proguanil at the same time each day with food or a milky drink. If you vomit within 1 hour after taking this medication, take another dose. If your vomiting continues, call your doctor.

If you are taking this medicine to prevent malaria, start taking it 1 or 2 days before entering an area where malaria is common. Take the medication every day during your stay and for at least 7 days after you leave. If you stop taking the medicine early for any reason, contact a healthcare professional about another form of malaria prevention.

If you are taking this medicine to treat malaria, take the medication every day for 3 days in a row.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

In addition to taking atovaquone and proguanil, use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

Contact your doctor as soon as possible if you have been exposed to malaria, or if you have a fever or other symptoms of illness during or after a stay in an area where malaria is common.

No medication is 100% effective in treating or preventing malaria. For best results, keep using the medication as directed. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment.

What should I discuss with my healthcare provider before taking atovaquone and proguanil?

You should not use this medication if you are allergic to atovaquone or proguanil. You should not use this medication to prevent malaria if you have severe kidney disease.

To make sure you can safely take atovaquone and proguanil, tell your doctor if you have any of these other conditions:

• 
  

  kidney disease;

  
  


• 
  

  liver disease;

  
  


• 
  

  severe complications from malaria; or

  
  


• 
  

  uncontrolled vomiting or diarrhea.

  
  

FDA pregnancy category C. It is not known whether atovaquone and proguanil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Malaria is more likely to cause death in a pregnant woman. If you are pregnant, talk with your doctor about the risks of traveling to areas where malaria is common. Atovaquone and proguanil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Atovaquone and proguanil should not be used to treat malaria in a child who weighs less than 11 pounds, and should not be used to prevent malaria in a child who weighs less than 24 pounds.

How should I take atovaquone and proguanil?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Use atovaquone and proguanil regularly to best prevent malaria. If you stop using the medication early for any reason, talk to your doctor about other forms of malaria prevention.

Take atovaquone and proguanil at the same time each day with food or a milky drink. If you vomit within 1 hour after taking this medication, take another dose. If your vomiting continues, call your doctor.

If you are taking this medicine to prevent malaria:

• 
  

  Start taking the medicine 1 or 2 days before entering an area where malaria is common. Continue taking the medicine every day during your stay and for at least 7 days after you leave the area.

  
  


• 
  

  If you stop taking the medicine early for any reason, contact a healthcare professional about another form of malaria prevention.

  
  

If you are taking this medicine to treat malaria:

• 
  

  Take the medicine every day for 3 days in a row.

  
  


• 
  

  Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

  
  

In addition to taking atovaquone and proguanil, use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

To be sure this medication is not causing harmful effects, your liver function will need to be checked with frequent blood tests. Visit your doctor regularly.

Contact your doctor as soon as possible if you have been exposed to malaria, or if you have fever or other symptoms of illness during or after a stay in an area where malaria is common.

No medication is 100% effective in treating or preventing malaria. For best results, keep using the medication as directed. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment.

Store at room temperature away from moisture and heat.

See also: Atovaquone and proguanil dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include stomach discomfort, vomiting, mouth sores, hair loss, easy bruising or bleeding, and peeling of the skin on your hands or feet.

What should I avoid while taking atovaquone and proguanil?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Atovaquone and proguanil side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  severe or uncontrolled vomiting or diarrhea;

  
  


• 
  

  fever, mouth sores;

  
  


• 
  

  problems with speech, balance, or walking;

  
  


• 
  

  severe skin rash;

  
  


• 
  

  nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); o

  
  


• 
  

  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

  
  

Less serious side effects may include:

• 
  

  mild stomach pain or upset stomach;

  
  


• 
  

  mild diarrhea;

  
  


• 
  

  headache;

  
  


• 
  

  mild itching;

  
  


• 
  

  weakness; or

  
  


• 
  

  dizziness.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Atovaquone and proguanil Dosing Information

Usual Adult Dose for Malaria:

1 g atovaquone/400 mg proguanil (four adult strength tablets as a single dose) orally once a day for 3 consecutive days

Usual Adult Dose for Malaria Prophylaxis:

Prophylactic therapy should start 1 or 2 days before entering a malaria-endemic area and continued daily during the stay and for 7 days after return.

250 mg atovaquone/100 mg proguanil (one adult strength tablet) orally once a day

Usual Pediatric Dose for Malaria:

Less than 5 kg ABW (actual body weight): Safety and efficacy has not been established.

5 to 8 kg ABW: 125 mg atovaquone/50 mg proguanil (2 pediatric tablets) once daily for 3 consecutive days.

9 to 10 kg ABW: 187.5 mg atovaquone/75 mg proguanil (3 pediatric tablets) once daily for 3 consecutive days.

11 to 20 kg ABW: 250 mg atovaquone/100 mg proguanil (one adult strength or four pediatric tablets as a single dose) orally once a day for 3 consecutive days

21 to 30 kg ABW: 500 mg atovaquone/200 mg proguanil (two adult strength tablets as a single dose) orally once a day for 3 consecutive days

31 to 40 kg ABW: 750 mg atovaquone/300 mg proguanil (three adult strength tablets as a single dose) orally once a day for 3 consecutive days

Greater than 40 kg ABW: 1 g atovaquone/400 mg proguanil (four adult strength tablets as a single dose) orally once a day for 3 consecutive days

Usual Pediatric Dose for Malaria Prophylaxis:

Prophylactic treatment should start 1 or 2 days before entering a malaria-endemic area and continued daily during the stay and for 7 days after return.

11 to 20 kg ABW (actual body weight): 62.5 mg atovaquone/25 mg proguanil (one pediatric tablet) orally once a day

21 to 30 kg ABW: 125 mg atovaquone/50 mg proguanil (two pediatric tablets as a single dose) orally once a day

31 to 40 kg ABW: 187.5 mg atovaquone/75 mg proguanil (three pediatric tablets as a single dose) orally once a day

Greater than 40 kg ABW: 250 mg atovaquone/100 mg proguanil (one adult strength tablet) orally once a day

What other drugs will affect atovaquone and proguanil?

Tell your doctor about all other medicines you use, especially:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  rifabutin (Mycobutin);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  tetracycline (Brodspec, Panmycin, Sumycin, Tetracap); or

  
  


• 
  

  metoclopramide (Reglan).

  
  

This list is not complete and other drugs may interact with atovaquone and proguanil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More atovaquone and proguanil resources

• Atovaquone and proguanil Side Effects (in more detail)
• Atovaquone and proguanil Dosage
• Atovaquone and proguanil Use in Pregnancy & Breastfeeding
• Atovaquone and proguanil Drug Interactions
• Atovaquone and proguanil Support Group
• 6 Reviews for Atovaquone and proguanil - Add your own review/rating

Compare atovaquone and proguanil with other medications

• Malaria
• Malaria Prevention

Where can I get more information?

• Your pharmacist can provide more information about atovaquone and proguanil.

See also: atovaquone and proguanil side effects (in more detail)

Aureomix

Dosage Form: FOR ANIMAL USE ONLY
Aureomix®

Granular 500

Chlortetracycline,

sulfamethazine, penicillin

Type A Medicated Article

Active drug ingredients

Chlortetracycline calcium complex equivalent to chlortetracycline HCl	40 g/lb
Sulfamethazine	8.8% (40 g/lb)
Penicillin (from procaine penicillin)	20 g/lb

Ingredients

Calcium sulfate and dried Streptomyces aureofaciens fermentation product.

Indications

For reduction of the incidence of cervical abscesses; treatment of bacterial swine enteritis (salmonellosis or necrotic enteritis caused by Salmonella choleraesuis and vibrionic dysentery); prevention of these diseases during times of stress; maintenance of weight gains in the presence of atrophic rhinitis; growth promotion and increased feed efficiency in swine weighing up to 75 pounds.

For use in the manufacture of swine feeds

Mixing directions

Use 2.5 lb Aureomix® 500 per 1 ton (907.2 kg) of final feed. Make a preblend of 2.5 lb of Aureomix® 500 with part (15-20 lb) of the feed ingredients. Mix thoroughly with the remainder of the ingredients to give a final concentration of 100 g chlortetracycline, 100 g sulfamethazine and 50 g penicillin per ton of feed.

Warning

Withdraw 15 days prior to slaughter

Restricted Drug (California) - use only as directed. Not for human use. NADA #35-688, Approved by FDA

Marketed by

ALPHARMA®

Alpharma, LLC

Bridgewater, New Jersey 08807

Net wt 50 LB (22.68 kg)

Made in USA

Trademarks

registered by

Alpharma, LLC

700356 1005

PRINCIPAL DISPLAY PANEL - 50 LB Label

Aureomix®

Granular 500

ALPHARMA

Chlortetracycline,

sulfamethazine, penicillin

Type A Medicated Article

See mixing directions, claims, cautions

and warnings on back

Net wt 50 LB (22.68 kg)

ALPHARMA®

Aureomix®

Granular 500

Aureomix  chlortetracycline hydrochloride, sulfamethazine, and penicillin g procaine  granule

Product Information Product Type OTC TYPE A MEDICATED ARTICLE ANIMAL DRUG NDC Product Code (Source) 46573-018 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Chlortetracycline Hydrochloride (Chlortetracycline) Chlortetracycline Hydrochloride 40 g  in 0.45 kg Sulfamethazine (Sulfamethazine) Sulfamethazine 40 g  in 0.45 kg Penicillin G Procaine (Penicillin G) Penicillin G Procaine 20 g  in 0.45 kg

Inactive Ingredients Ingredient Name Strength Calcium Sulfate

Product Characteristics Color GRAY (Gray to Brown) Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 46573-018-00 22.68 kg In 1 BAG None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA035688	01/01/2009

Labeler - Alpharma, LLC. (070954094)

Revised: 11/2010Alpharma, LLC.

Fucidin Ointment

Fucidin Ointment

sodium fusidate

Please read all of this leaflet carefully before you start taking this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them,
  even if their symptoms are the same as yours.


• If any of the side effects become serious, or you notice any side effects not listed in this
  leaflet please tell your doctor or pharmacist.

In this leaflet:

• 1. What Fucidin Ointment is and what it is used for


• 2. Before you use Fucidin Ointment


• 3. How to use Fucidin Ointment


• 4. Possible side effects


• 5. How to store Fucidin Ointment


• 6. Further information

What Fucidin Ointment Is And What It Is Used For

Fucidin Ointment contains sodium fusidate. It is a type of antibiotic.

Fucidin Ointment works by killing germs (bacteria) that cause infections.

Fucidin Ointment is used to treat conditions where the skin is infected by germs (bacteria), such as:

• Impetigo (a weeping, crusty and swollen patch of skin)


• Infected dermatitis (inflammation of the skin) and spots


• Infected cuts and grazes.

Before You Use Fucidin Ointment

Do not use Fucidin Ointment

• If you are allergic (hypersensitive) to fusidic acid or sodium fusidate.


• If you are allergic (hypersensitive) to any of the other ingredients in your medicine. You can find a list of these ingredients in section 6 of this leaflet.

Take special care with Fucidin Ointment

• Take special care if you are going to use this medicine near your eyes or the eyes of a child.


• If you use the ointment over a long time or in large amounts it may make the chance of getting any side effects higher. Also your skin may get more sensitive to this medicine.

Taking other medicines

Please tell your doctor or pharmacist if you are taking, or have recently taken any other medicines. This includes any medicines which you have bought without a prescription.

Pregnancy and breast-feeding

Please ask your doctor or pharmacist for advice before using Fucidin Ointment:

• If you are pregnant, or think you are pregnant. You must not use your medicine for a long time or in large amounts. You must ask your doctor for advice.


• If you are breast-feeding.

Tell your doctor if you become pregnant while using this medicine.

Driving and using machines

Usually your medicine will have very little effect on your ability to drive or use machines. Check with your doctor if you feel any side effect that may stop you from driving or using machines.

Important information about some of the ingredients of Fucidin Ointment

Fucidin Ointment contains:

• Lanolin (wool fat). This may give you an itchy rash and inflammation on your skin where your medicine is used.


• Cetyl alcohol. This may give you an itchy rash and inflammation on your skin where your medicine is used.

Please ask your doctor if you are worried about any of the ingredients in this medicine.

How To Use Fucidin Ointment

Always use Fucidin Ointment exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

How to put on Fucidin Ointment

This medicine is only for using on your skin or the skin of a child. Do not swallow it. Do not put it inside your body.

Remove the cap. Check the seal is not broken before you first use the ointment. Then push the spike in the cap through the seal on the tube.

Always wash your hands before using Fucidin Ointment. Rub the medicine gently on the skin. If you use it on your face be careful to avoid your eyes.

Unless you are using the ointment to treat your hands, always wash your hands after using Fucidin Ointment.

If you accidentally get any medicine in your eye, wash it out with cold water straight away. Then bathe your eye with eyewash if possible. Your eye may sting. If you start to have any problems with your sight or your eye is sore, contact your doctor immediately.

How much Fucidin Ointment to use

Your doctor will tell you how much Fucidin Ointment to use.

Usually, you should use this medicine three or four times each day.

If you have been told to cover the skin with any dressings or bandages you may not need to use the medicine so often. A nappy on a baby may act as a dressing. Follow the advice of your doctor.

If you forget to use Fucidin Ointment

If you forget to use this medicine, use it as soon as you remember. Then next use this medicine at the usual time.

If you have any further questions about using this medicine, please ask your doctor or pharmacist.

Fucidin Ointment Side Effects

Like all medicines, Fucidin Ointment can cause side effects, although not everybody gets them.

Important side effects to look out for:

You must get urgent medical help if you have any of the following symptoms. You may be having an allergic reaction:

• You have difficulty breathing


• Your face or throat swell


• Your skin develops a severe rash.

Other possible side effects:

Skin problems

• Rash


• Stinging and irritation


• Itchy rash and skin inflammation in the area where the medicine is used.

If any of the side effects become serious or you notice any side effects not listed in this leaflet, tell your doctor or pharmacist.

How To Store Fucidin Ointment

• Keep out of the reach and the sight of children.


• Do not use Fucidin Ointment after the expiry date on the carton. The expiry date is the last day of that month.

Medicines should not be thrown away in waste water or in household waste. Please ask your pharmacist how to throw away any medicine you do not need any more. If you do this you will help protect the environment.

Further Information

What Fucidin Ointment contains

• The active ingredient is sodium fusidate 2%.


• The other ingredients are cetyl alcohol, lanolin (wool fat), liquid paraffin and white soft paraffin.

You can find important information about some of the ingredients in your medicine near the end of section 2 of this leaflet.

What Fucidin Ointment looks like and contents of the pack

Fucidin Ointment is an off white ointment.

Fucidin Ointment comes in tubes of 15 g and 30 g.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder:

LEO Laboratories Limited

Princes Risborough

Bucks.

HP27 9RR

UK

Manufacturer:

LEO Laboratories Limited

Dublin 12

Ireland

This leaflet was last revised in March 2008.

Registered Trade Mark

LEO

014156-03

Ampicillin

Pronunciation: AM-pi-SIL-in
Generic Name: Ampicillin
Brand Name: Principen

Ampicillin is used for:

Treating infections caused by certain types of bacteria.

Ampicillin is a penicillin antibiotic. It works by killing sensitive bacteria by interfering with formation of the bacteria's cell wall while it is growing. This weakens the cell wall and it ruptures, resulting in the death of the bacteria.

Do NOT use Ampicillin if:

• you are allergic to any ingredient in Ampicillin or to any other penicillin antibiotic (eg, amoxicillin)


• you are taking a tetracycline antibiotic (eg, doxycycline)


• you have mononucleosis ("mono")


• you have recently received or will be receiving live oral typhoid vaccine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ampicillin:

Some medical conditions may interact with Ampicillin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a stomach infection or diarrhea


• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a cephalosporin antibiotic (eg, cephalexin) or other beta-lactam antibiotic (eg, imipenem)

Some MEDICINES MAY INTERACT with Ampicillin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Tetracyclines (eg, doxycycline) because they may decrease Ampicillin's effectiveness


• Probenecid because it may increase the risk of Ampicillin's side effects


• Allopurinol because the risk of skin rash may be increased


• Anticoagulants (heparin, warfarin) or methotrexate because the risk of their side effects may be increased by Ampicillin


• Aminoglycosides (eg, gentamicin), birth control pills, or live oral typhoid vaccine because their effectiveness may be decreased by Ampicillin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ampicillin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ampicillin:

Use Ampicillin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ampicillin by mouth at least one-half hour before or 2 hours after eating.


• Take Ampicillin with a full glass of water (8 oz/240 mL).


• Take Ampicillin on a regular schedule to get the most benefit from it. Taking Ampicillin at the same time each day will help you remember to take it.


• To clear up your infection completely, use Ampicillin for the full course of treatment. Keep using it even if you feel better in a few days.


• If you miss a dose of Ampicillin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ampicillin.

Important safety information:

• Ampicillin only works against bacteria; it does not treat viral infections (eg, the common cold).


• Be sure to use Ampicillin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Ampicillin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Ampicillin. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Diabetes patients - Ampicillin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.


• Lab tests, including white blood cell counts and kidney function tests, may be performed while you use Ampicillin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Ampicillin with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ampicillin while you are pregnant. Ampicillin is found in breast milk. If you are or will be breast-feeding while you use Ampicillin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ampicillin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Inflammation and redness of the tongue; irritation of mouth or throat; mild diarrhea; nausea; second infection; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; severe diarrhea; stomach pain/cramps; vaginal irritation or discharge .

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ampicillin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; nausea; seizures; vomiting.

Proper storage of Ampicillin:

Store Ampicillin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Keep Ampicillin out of the reach of children and away from pets.

General information:

• If you have any questions about Ampicillin, please talk with your doctor, pharmacist, or other health care provider.


• Ampicillin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ampicillin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ampicillin resources

• Ampicillin Side Effects (in more detail)
• Ampicillin Dosage
• Ampicillin Use in Pregnancy & Breastfeeding
• Drug Images
• Ampicillin Drug Interactions
• Ampicillin Support Group
• 3 Reviews for Ampicillin - Add your own review/rating

• Ampicillin Prescribing Information (FDA)


• Ampicillin Monograph (AHFS DI)


• Ampicillin Professional Patient Advice (Wolters Kluwer)


• ampicillin Concise Consumer Information (Cerner Multum)


• Ampicillin Sodium and Sulbactam Sodium Monograph (AHFS DI)


• Principen Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Ampicillin with other medications

• Bacterial Endocarditis Prevention
• Bronchitis
• Endocarditis
• Gastroenteritis
• Intraabdominal Infection
• Kidney Infections
• Leptospirosis
• Meningitis
• Otitis Media
• Peritonitis
• Pharyngitis
• Pneumonia
• Prevention of Perinatal Group B Streptococcal Disease
• Septicemia
• Shigellosis
• Sinusitis
• Skin Infection
• Surgical Prophylaxis
• Typhoid Fever
• Upper Respiratory Tract Infection
• Urinary Tract Infection

Faslodex

Pronunciation: fool-VES-trant
Generic Name: Fulvestrant
Brand Name: Faslodex

Faslodex is used for:

Treating certain types of advanced breast cancer in women after menopause who have not responded well to other medicines (eg, antiestrogen drugs) or therapy. It may also be used for other conditions as determined by your doctor.

Faslodex is an estrogen receptor antagonist. It works by blocking estrogen from tumors that need estrogen to grow.

Do NOT use Faslodex if:

• you are allergic to any ingredient in Faslodex


• you are pregnant


• you are taking an anticoagulant (eg, warfarin, heparin)


• you have low blood platelet levels or a history of bleeding or blood clotting problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Faslodex:

Some medical conditions may interact with Faslodex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you plan to become pregnant or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have liver problems

Some MEDICINES MAY INTERACT with Faslodex. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, heparin, warfarin) because risk of bleeding may be increased by Faslodex

This may not be a complete list of all interactions that may occur. Ask your health care provider if Faslodex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Faslodex:

Use Faslodex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Faslodex is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Faslodex at home, carefully follow the injection procedures taught to you by your health care provider.


• If Faslodex contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Faslodex, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Faslodex.

Important safety information:

• Faslodex may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Faslodex. Using Faslodex alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks


• Avoid becoming pregnant while you are using Faslodex. Your doctor should make sure that you are not pregnant before you begin using Faslodex.


• Use Faslodex with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Faslodex if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if Faslodex is excreted in breast milk. Do not breast-feed while taking Faslodex.

Possible side effects of Faslodex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; anxiety; back, bone, joint, or pelvic pain; constipation; diarrhea; dizziness; headache; hot flushes; increased cough; loss of appetite; nausea; pain, swelling, or redness at the injection site; sleeplessness; sore throat; stomach pain; sweating; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; depression; fever or chills; frequent or painful urination; mental or mood changes; pain, redness, or tenderness in the legs; persistent sore throat; persistent vaginal bleeding; severe tiredness or weakness; shortness of breath; swelling of the hands or feet.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Faslodex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Faslodex:

Store Faslodex in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), in the original carton. Do not freeze. Keep Faslodex out of the reach of children and away from pets.

General information:

• If you have any questions about Faslodex, please talk with your doctor, pharmacist, or other health care provider.


• Faslodex is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Faslodex. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Faslodex resources

• Faslodex Side Effects (in more detail)
• Faslodex Use in Pregnancy & Breastfeeding
• Faslodex Support Group
• 2 Reviews for Faslodex - Add your own review/rating

• Faslodex Prescribing Information (FDA)


• Faslodex Consumer Overview


• Faslodex Monograph (AHFS DI)


• Faslodex Advanced Consumer (Micromedex) - Includes Dosage Information


• Fulvestrant Professional Patient Advice (Wolters Kluwer)

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